SH3BP2 抗体 (AA 256-561)
Quick Overview for SH3BP2 抗体 (AA 256-561) (ABIN7600936)
抗原
See all SH3BP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 256-561
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原理
- Anti-3BP2/SH3BP2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-3BP2/SH3BP2 Antibody Picoband® (ABIN7600936). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human 3BP2/SH3BP2 recombinant protein (Position: R256-R561).
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亚型
- IgG
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anti-SH3-Domain Binding Protein 2 (SH3BP2) (AA 452-561) antibody
SH3BP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-SH3-Domain Binding Protein 2 (SH3BP2) (AA 432-481) antibodySH3BP2 适用: 人, 小鼠, 大鼠, 猴, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Binding Protein 2 (SH3BP2) (AA 165-301) antibodySH3BP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Binding Protein 2 (SH3BP2) antibodySH3BP2 适用: 小鼠 WB 宿主: 绵羊 Polyclonal unconjugated
anti-SH3-Domain Binding Protein 2 (SH3BP2) (AA 1-561) antibodySH3BP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SH3-Domain Binding Protein 2 (SH3BP2) (AA 392-561) antibodySH3BP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg /1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bell, S. M., Shaw, M., Jou, Y.-S., Myers, R. M., Knowles, M. A. Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer. Genomics 44: 163-170, 1997. 2. Lo, B., Faiyaz-Ul-Haque, M., Kennedy, S., Aviv, R., Tsui, L.-C., Teebi, A. S. Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism. Am. J. Med. Genet. 121A: 37-40, 2003. 3. Ueki, Y., Lin, C.-Y., Senoo, M., Ebihara, T., Agata, N., Onji, M., Saheki, Y., Kawai, T., Mukherjee, P. M., Reichenberger, E., Olsen, B. R. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell 128: 71-83, 2007. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))
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别名
- SH3BP2
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背景
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Synonyms: Ran-specific GTPase-activating protein,Ran-binding protein 1,RanBP1,RANBP1,
Tissue Specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Background: SH3BP2 (SH3 domain-binding protein 2) is a protein that comes from a gene located on Chromosome 4. The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
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分子量
- 70 kDa
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基因ID
- 6452
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UniProt
- P78314
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途径
- TCR Signaling
抗原
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