Rhotekin 抗体 (AA 255-554)
Quick Overview for Rhotekin 抗体 (AA 255-554) (ABIN7600934)
抗原
See all Rhotekin (RTKN) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 255-554
-
原理
- Anti-RTKN Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-RTKN Antibody Picoband® (ABIN7600934). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human RTKN recombinant protein (Position: R255-Q554).
-
亚型
- IgG
-
-
anti-Rhotekin (RTKN) antibody
RTKN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-Rhotekin (RTKN) (AA 451-549) antibodyRTKN 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Rhotekin (RTKN) (AA 304-563) antibodyRTKN 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin (RTKN) (AA 254-513) antibodyRTKN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin (RTKN) (AA 296-548) antibodyRTKN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin (RTKN) antibodyRTKN 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin (RTKN) (AA 451-549) antibodyRTKN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Rhotekin (RTKN) (AA 451-550) antibodyRTKN 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Rhotekin (RTKN) (AA 431-480) antibodyRTKN 适用: 人, 大鼠, 小鼠, 犬, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Rhotekin (RTKN) (AA 107-156) antibodyRTKN 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Jang, W., Weber, J. S., Harkins, E. B., Meisler, M. H. Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B. Genomics 40: 506-507, 1997. 2. Reid, T., Furuyashiki, T., Ishizaki, T., Watanabe, G., Watanabe, N., Fujisawa, K., Morii, N., Madaule, P., Narumiya, S. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the Rho-binding domain. J. Biol. Chem. 271: 13556-13560, 1996. 3. Sudo, K., Ito, H., Iwamoto, I., Morishita, R., Asano, T., Nagata, K. Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, rhotekin, and their possible interaction in neurons. Neurosci. Res. 56: 347-355, 2006. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- Rhotekin (RTKN)
-
别名
- RTKN
-
背景
-
Synonyms: C-C motif chemokine 16, Chemokine CC-4, HCC-4, Chemokine LEC, IL-10-inducible chemokine, LCC-1, Liver-expressed chemokine, Lymphocyte and monocyte chemoattractant, LMC, Monotactin-1, MTN-1, NCC-4, Small-inducible cytokine A16, CCL16, ILINCK, NCC4, SCYA16
Tissue Specificity: Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Background: Rhotekin is a protein that in humans is encoded by the RTKN gene. This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
-
分子量
- 70 kDa
-
基因ID
- 6242
抗原
-
