RNASEH2A 抗体 (AA 25-299)
Quick Overview for RNASEH2A 抗体 (AA 25-299) (ABIN7600899)
抗原
See all RNASEH2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-299
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原理
- Anti-Ribonuclease H2, subunit A/RNASEH2A Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Ribonuclease H2, subunit A/RNASEH2A Antibody Picoband® (ABIN7600899). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Ribonuclease H2, subunit A/RNASEH2A recombinant protein (Position: R25-L299).
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亚型
- IgG
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anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibody
RNASEH2A 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3G5-F5 unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-301) antibodyRNASEH2A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人, 斑马鱼, Cow, 马, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (Middle Region) antibodyRNASEH2A 适用: 人, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-301) antibodyRNASEH2A 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Coffin, S. R., Hollis, T., Perrino, F. W. Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome. J. Biol. Chem. 286: 16984-16991, 2011. 2. Crow, Y. J., Leitch, A., Hayward, B. E., Garner, A., Parmar, R., Griffith, E., Ali, M., Semple, C., Aicardi, J., Babul-Hirji, R., Baumann, C., Baxter, P., and 33 others. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nature Genet. 38: 910-916, 2006. 3. Frank, P., Braunshofer-Reiter, C., Wintersberger, U., Grimm, R., Busen, W. Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII. Proc. Nat. Acad. Sci. 95: 12872-12877, 1998. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
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别名
- RNASEH2A
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背景
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Synonyms: Mucin-20, MUC-20, MUC20, KIAA1359, UNQ2782/PRO7170
Tissue Specificity: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
Background: Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene. The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
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分子量
- 33 kDa
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基因ID
- 10535
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UniProt
- O75792
抗原
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