PDE6B 抗体 (AA 25-237)
Quick Overview for PDE6B 抗体 (AA 25-237) (ABIN7600893)
抗原
See all PDE6B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 25-237
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原理
- Anti-PDE6 beta/PDE6B Antibody Picoband® (monoclonal, 8I2F10)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PDE6 beta/PDE6B Antibody Picoband® (monoclonal, 8I2F10) (ABIN7600893). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PDE6 beta/PDE6B recombinant protein (Position: K25-Q237).
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亚型
- IgG2b
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anti-phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (AA 1-190) antibody
PDE6B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) antibodyPDE6B 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (AA 1-853) antibodyPDE6B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (AA 105-154) antibodyPDE6B 适用: 人, Cow, 犬, 马, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (AA 372-421) antibodyPDE6B 适用: 人, Cow, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x6 cells, Human
1. Hmani-Aifa, M., Benzina, Z., Zulfiqar, F., Dhouib, H., Shahzadi, A., Ghorbel, A., Rebai, A., Soderkvist, P., Riazuddin, S., Kimberling, W. J., Ayadi, H. Identification of two new mutations in the GPR98 and the PDE6B genes segregating in a Tunisian family. Europ. J. Hum. Genet. 17: 474-482, 2009. 2. Tsang, S. H., Woodruff, M. L., Jun, L., Mahajan, V., Yamashita, C. K., Pedersen, R., Lin, C.-S., Goff, S. P., Rosenberg, T., Larsen, M., Farber, D. B., Nusinowitz, S. Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum. Mutat. 28: 243-254, 2007. 3. Zhao, L., Zabel, M. K., Wang, X., Ma, W., Shah, P., Fariss, R. N., Qian, H., Parkhurst, C. N., Gan, W.-B., Wong, W. T. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Molec. Med. 7: 1179-1197, 2015. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))
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别名
- PDE6B
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背景
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Synonyms: Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA
Background: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
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分子量
- 98 kDa
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基因ID
- 5158
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UniProt
- P35913
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
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