AANAT 抗体 (AA 24-205)
Quick Overview for AANAT 抗体 (AA 24-205) (ABIN7600815)
抗原
See all AANAT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-205
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原理
- Anti-Aanat Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Aanat Antibody Picoband® (ABIN7600815). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse Aanat recombinant protein (Position: C24-C205).
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亚型
- IgG
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anti-Aralkylamine N-Acetyltransferase (AANAT) (AA 141-207) antibody
AANAT 适用: 人, 大鼠, 小鼠, 绵羊 ELISA, WB, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aralkylamine N-Acetyltransferase (AANAT) (AA 22-235) antibodyAANAT 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Aralkylamine N-Acetyltransferase (AANAT) (AA 1-207) antibodyAANAT 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Coon, S. L., del Olmo, E., Young, W. S., III, Klein, D. C. Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). J. Clin. Endocr. Metab. 87: 4699-4706, 2002. 2. Coon, S. L., Mazuruk, K., Bernard, M., Roseboom, P. H., Klein, D. C., Rodriguez, I. R. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics 34: 76-84, 1996. 3. Coon, S. L., Roseboom, P. H., Baler, R., Weller, J. L., Namboodiri, M. A. A., Koonin, E. V., Klein, D. C. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science 270: 1681-1683, 1995. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- AANAT (Aralkylamine N-Acetyltransferase (AANAT))
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别名
- Aanat
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背景
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Synonyms: S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin, SAG,
Tissue Specificity: Retina and pineal gland.
Background: Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants.
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分子量
- 23 kDa
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基因ID
- 11298
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UniProt
- O88816
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途径
- Photoperiodism
抗原
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