ATR 抗体 (AA 24-1324)
Quick Overview for ATR 抗体 (AA 24-1324) (ABIN7600806)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-1324
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原理
- Anti-ATR Antibody
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-ATR Antibody Picoband® (ABIN7600806). Tested in ELISA, IF, ICC applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ATR recombinant protein (Position: E24-D1324).
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亚型
- IgG
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应用备注
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Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Alderton, G. K., Joenje, H., Varon, R., Borglum, A. D., Jeggo, P. A., O'Driscoll, M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum. Molec. Genet. 13: 3127-3138, 2004. 2. Bao, S., Tibbetts, R. S., Brumbaugh, K. M., Fang, Y., Richardson, D. A., Ali, A., Chen, S. M., Abraham, R. T., Wang, X.-F. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411: 969-974, 2001. 3. Brown, E. J., Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14: 397-402, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- ATR (ATR serine/threonine kinase (ATR))
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别名
- ATR
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背景
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Synonyms: Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, bHLHe5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3, ARNTL, BHLHE5, BMAL1, MOP3, PASD3
Tissue Specificity: Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
Background: Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
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分子量
- 301 kDa
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基因ID
- 545
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UniProt
- Q13535
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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