Innate Immunity Activator Protein (C1ORF106) (AA 236-663) 抗体
This anti-Innate Immunity Activator Protein antibody is a 兔 多克隆 antibody detecting Innate Immunity Activator Protein in ELISA 和 WB. Suitable for 人.
产品编号 ABIN7600790
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for Innate Immunity Activator Protein (C1ORF106) (AA 236-663) 抗体 (ABIN7600790)
抗原
Innate Immunity Activator Protein (C1ORF106)
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
ELISA, Western Blotting (WB)
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抗原表位
- AA 236-663
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原理
- Anti-INAVA Antibody
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产品特性
- Anti-INAVA Antibody (ABIN7600790). Tested in WB, ELISA applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human INAVA recombinant protein (Position: Q236-V663). Human INAVA shares 85.3% amino acid (aa) sequence identity with mouse INAVA.
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亚型
- IgG
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Innate Immunity Activator Protein (C1ORF106)
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别名
- INAVA
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背景
- INAVA, sometimes referred to as hypothetical protein LOC55765, is a protein of unknown function that in humans is encoded by the INAVA gene. Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).
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分子量
- 70 kDa
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基因ID
- 55765
抗原
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