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L1CAM 抗体 (AA 223-1218)

This anti-L1CAM antibody is a 兔 多克隆 antibody detecting L1CAM in WB, FACS 和 ELISA. Suitable for 人 和 大鼠.
产品编号 ABIN7600711
发货至: 中国

Quick Overview for L1CAM 抗体 (AA 223-1218) (ABIN7600711)

抗原

See all L1CAM 抗体
L1CAM (L1 Cell Adhesion Molecule (L1CAM))

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This L1CAM antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), ELISA
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    AA 223-1218

    原理

    Anti-L1CAM Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-L1CAM Antibody Picoband® (ABIN7600711). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human L1CAM recombinant protein (Position: E223-Q1218).

    亚型

    IgG
  • 应用备注

    Western blot, 0.25-0.5 μg/mL, Human, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Basel-Vanagaite, L., Straussberg, R., Friez, M. J., Inbar, D., Korenreich, L., Shohat, M., Schwartz, C. E. Expanding the phenotypic spectrum of L1CAM-associated disease. Clin. Genet. 69: 414-419, 2006. 2. Du, Y.-Z., Dickerson, C., Aylsworth, A. S., Schwartz, C. E. A silent mutation, C924T (G308G), in the L1CAM gene results in X linked hydrocephalus (HSAS). J. Med. Genet. 35: 456-462, 1998.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    储存条件

    4 °C,-20 °C

    储存方法

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原

    L1CAM (L1 Cell Adhesion Molecule (L1CAM))

    别名

    L1CAM

    背景

    Synonyms: Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5

    Tissue Specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.

    Background: L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

    分子量

    220 kDa

    基因ID

    3897

    UniProt

    P32004

    途径

    Synaptic Membrane
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