C6orf150 抗体 (AA 208-522)
Quick Overview for C6orf150 抗体 (AA 208-522) (ABIN7600586)
抗原
See all C6orf150 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 208-522
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原理
- Anti-CGAS Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CGAS Antibody Picoband® (ABIN7600586). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CGAS recombinant protein (Position: L208-F522).
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亚型
- IgG
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anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 211-395) antibody
C6orf150 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 350-522) antibodyC6orf150 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 1-185) antibodyC6orf150 适用: 人 WB 宿主: 小鼠 Monoclonal 7E3 unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (pSer420) antibodyC6orf150 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 225-407) antibodyC6orf150 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (Middle Region) antibodyC6orf150 适用: 人, 兔, Cow, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 273-303), (Middle Region) antibodyC6orf150 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ablasser, A., Hemmerling, I., Schmid-Burgk, J. L., Behrendt, R., Roers, A., Hornung, V. TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner. J. Immun. 192: 5993-5997, 2014. 2. Ablasser, A., Schmid-Burgk, J. L., Hemmerling, I., Horvath, G. L., Schmidt, T., Latz, E., Hornung, V. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503: 530-534, 2013. 3. Andreeva, L., Hiller, B., Kostrewa, D., Lassig, C., de Oliveira Mann, C. C., Drexler, D. J., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., Hopfner, K.-P. cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders Nature 549: 394-398, 2017. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
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别名
- CGAS
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背景
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Synonyms: Lymphocyte antigen 6A-2/6E-1,Ly-6A.2/Ly-6E.1,Stem cell antigen 1,SCA-1,T-cell-activating protein,TAP,Ly6a,Ly6,
Tissue Specificity: Widely expressed. .
Background: cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.
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分子量
- 62 kDa
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基因ID
- 115004
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UniProt
- Q8N884
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途径
- Activation of Innate immune Response
抗原
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