Prosaposin 抗体 (AA 182-479)
Quick Overview for Prosaposin 抗体 (AA 182-479) (ABIN7600369)
抗原
See all Prosaposin (PSAP) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 182-479
-
原理
- Anti-PSAP Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-PSAP Antibody Picoband® (ABIN7600369). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human PSAP recombinant protein (Position: Q182-I479).
-
亚型
- IgG
-
-
anti-Prosaposin (PSAP) (AA 325-524) antibody
PSAP 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4D5F4 unconjugated
anti-Prosaposin (PSAP) (AA 17-524) antibodyPSAP 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prosaposin (PSAP) (AA 60-310) antibodyPSAP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Prosaposin (PSAP) (AA 17-216) antibodyPSAP 适用: 人, 大鼠 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3B4A8 unconjugated
anti-Prosaposin (PSAP) (AA 18-524) antibodyPSAP 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 1D1-C12 unconjugated
anti-Prosaposin (PSAP) (AA 325-524) antibodyPSAP 适用: 人 WB, IHC, ELISA, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Prosaposin (PSAP) (AA 311-391) antibodyPSAP 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Prosaposin (PSAP) (AA 1-524) antibodyPSAP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-Prosaposin (PSAP) (Internal Region) antibodyPSAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Prosaposin (PSAP) antibodyPSAP 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-452M unconjugated Recombinant Antibody
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Azuma, N., O'Brien, J. S., Moser, H. W., Kishimoto, Y. Stimulation of acid ceramidase activity by saposin D. Arch. Biochem. Biophys. 311: 354-357, 1994. 2. Bar-Am, I., Avivi, L., Horowitz, M. Assignment of the human prosaposin gene (PSAP) to 10q22.1 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 72: 316-318, 1996. 3. Bradova, V., Smid, F., Ulrich-Bott, B., Roggendorf, W., Paton, B. C., Harzer, K. Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphingolipid storage disease. Hum. Genet. 92: 143-152, 1993. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- Prosaposin (PSAP)
-
别名
- PSAP
-
背景
-
Synonyms: Tafazzin, Protein G4.5, TAZ, EFE2, G4.5
Tissue Specificity: High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.
Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
-
分子量
- 70 kDa
-
基因ID
- 5660
-
UniProt
- P07602
-
途径
- Positive Regulation of Endopeptidase Activity
抗原
-
