TUBB1 抗体 (AA 18-435)
Quick Overview for TUBB1 抗体 (AA 18-435) (ABIN7600343)
抗原
See all TUBB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-435
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原理
- Anti-Tubulin beta Antibody Picoband®
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-Tubulin beta Antibody Picoband® (ABIN7600343). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Tubulin beta recombinant protein (Position: A18-D435).
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亚型
- IgG
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Davis, B., Toivio-Kinnucan, M., Schuller, S., Boudreaux, M. K. Mutation in beta-1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. J. Vet. Intern. Med. 22: 540-545, 2008. 2. Freson, K., De Vos, R., Wittevrongel, C., Thys, C., Defoor, J., Vanhees, L., Vermylen, J., Peerlinck, K., Van Geet, C. The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure. Blood 106: 2356-2362, 2005. 3. Kunishima, S., Kobayashi, R., Itoh, T. J., Hamaguchi, M., Saito, H. Mutation of the beta-1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Blood 113: 458-461, 2009. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- TUBB1 (Tubulin, beta 1 (TUBB1))
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别名
- TUBB1
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背景
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Synonyms: RNA binding protein fox-1 homolog 2, Fox-1 homolog B, Hexaribonucleotide-binding protein 2, RNA-binding motif protein 9, RNA-binding protein 9, Repressor of tamoxifen transcriptional activity, RBFOX2, FOX2, HRNBP2, RBM9, RTA
Tissue Specificity: Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.
Background: TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.
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分子量
- 55 kDa
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基因ID
- 81027
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UniProt
- Q9H4B7
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途径
- Microtubule Dynamics
抗原
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