DLGAP1 抗体 (AA 17-319)
Quick Overview for DLGAP1 抗体 (AA 17-319) (ABIN7600257)
抗原
See all DLGAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 17-319
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原理
- Anti-DLGAP1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-DLGAP1 Antibody Picoband® (ABIN7600257). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human DLGAP1 recombinant protein (Position: D17-Q319).
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亚型
- IgG
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anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) antibody
DLGAP1 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (AA 1-100) antibodyDLGAP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A6 unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (Internal Region) antibodyDLGAP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (C-Term) antibodyDLGAP1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (C-Term) antibodyDLGAP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (AA 162-190), (N-Term) antibodyDLGAP1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB19603 unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (AA 791-840) antibodyDLGAP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1) (AA 397-411), (Intracellular) antibodyDLGAP1 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Gross, M. B. Personal Communication. Baltimore, Md. 5/20/2014. 2. Kim, E., Naisbitt, S., Hsueh, Y.-P., Rao, A., Rothschild, A., Craig, A. M., Sheng, M. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J. Cell Biol. 136: 669-678, 1997. 3. Satoh, K., Yanai, H., Senda, T., Kohu, K., Nakamura, T., Okumura, N., Matsumine, A., Kobayashi, S., Toyoshima, K., Akiyama, T. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells 2: 415-424, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- DLGAP1 (Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1))
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别名
- DLGAP1
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背景
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Synonyms: Transforming growth factor beta activator LRRC32, Garpin, Glycoprotein A repetitions predominant, GARP, Leucine-rich repeat-containing protein 32, LRRC32, D11S833E
Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Background: Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing. It is composed of numerous proteins including a family of Discs large associated protein 1, 2, 3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density. They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors, to signalling proteins and to components of the cytoskeleton. With the central localisation in the postsynapse, the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity. DLGAP family has been ly linked to a variety of psychological and neurological disorders.
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分子量
- 130 kDa
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基因ID
- 9229
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UniProt
- O14490
抗原
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