Gephyrin 抗体 (AA 148-736)
Quick Overview for Gephyrin 抗体 (AA 148-736) (ABIN7600086)
抗原
See all Gephyrin (GPHN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 148-736
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原理
- Anti-Gephyrin/GPHN Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Gephyrin/GPHN Antibody Picoband® (ABIN7600086). Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Gephyrin/GPHN recombinant protein (Position: K148-L736).
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亚型
- IgG
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anti-Gephyrin (GPHN) antibody
GPHN 适用: 人, 猴 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Gephyrin (GPHN) antibodyGPHN 适用: 人, 大鼠, 猴 WB, FACS 宿主: 小鼠 Monoclonal 3A6 unconjugated
anti-Gephyrin (GPHN) (AA 360-460) antibodyGPHN 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) antibodyGPHN 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 677-769) antibodyGPHN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 520-769) antibodyGPHN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 437-466) antibodyGPHN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24625 unconjugated
anti-Gephyrin (GPHN) (AA 444-474), (Middle Region) antibodyGPHN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 1-769) antibodyGPHN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 396-445) antibodyGPHN 适用: 人, 小鼠, 大鼠, 斑马鱼, 小鸡, 猴, Cow, 犬, 豚鼠, 马, 兔, 非洲爪蟾, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat, Monkey
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Butler, M. H., Hayashi, A., Ohkoshi, N., Villmann, C., Becker, C.-M., Feng, G., De Camilli, P., Solimena, M. Autoimmunity to gephyrin in stiff-man syndrome. Neuron 26: 307-312, 2000. 2. Eguchi, M., Eguchi-Ishimae, M., Greaves, M. The small oligomerization domain of gephyrin converts MLL to an oncogene. Blood 103: 3876-3882, 2004. 3. Eguchi, M., Eguchi-Ishimae, M., Seto, M., Morishita, K., Suzuki, K., Ueda, R., Ueda, K., Kamada, N., Greaves, M. GPHN, a novel partner gene fused to MLL in a leukemia with t(11,14)(q23,q24). Genes Chromosomes Cancer 32: 212-221, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Gephyrin (GPHN)
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别名
- GPHN
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背景
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Synonyms: Lymphotactin, C motif chemokine 1, Cytokine SCM-1, Lymphotaxin, Small-inducible cytokine C1, Xcl1, Lptn, Ltn, Scyc1
Tissue Specificity: Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
Background: Gephyrin is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known.
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分子量
- 93 kDa
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基因ID
- 10243
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途径
- Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
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