PHEX 抗体 (AA 145-718)
Quick Overview for PHEX 抗体 (AA 145-718) (ABIN7600072)
抗原
See all PHEX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 145-718
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原理
- Anti-PHEX Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PHEX Antibody Picoband® (ABIN7600072). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PHEX recombinant protein (Position: E145-N718).
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亚型
- IgG
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anti-Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) (AA 524-673) antibody
PHEX 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) (AA 1-749) antibodyPHEX 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) antibodyPHEX 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Monkey, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Christie, P. T., Harding, B., Nesbit, M. A., Whyte, M. P., Thakker, R. V. X-linked hypophosphatemia attributable to pseudoexons of the PHEX gene. J. Clin. Endocr. Metab. 86: 3840-3844, 2001. 2. Dixon, P. H., Christie, P. T., Wooding, C., Trump, D., Grieff, M., Holm, I., Gertner, J. M., Schmidtke, J., Shah, B., Shaw, N., Smith, C., Tau, C., Schlessinger, D., Whyte, M. P., Thakker, R. V. Mutational analysis of PHEX gene in X-linked hypophosphatemia. J. Clin. Endocr. Metab. 83: 3615-3623, 1998. 3. Econs, M. J., Friedman, N. E., Rowe, P. S. N., Speer, M. C., Francis, F., Strom, T. M., Oudet, C., Smith, J. A., Ninomiya, J. T., Lee, B. E., Bergen, H. A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets. J. Clin. Endocr. Metab. 83: 3459-3462, 1998. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PHEX (Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX))
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别名
- PHEX
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背景
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Synonyms: Phosphate-regulating neutral endopeptidase PHEX, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX
Tissue Specificity: Specifically expressed in ovary. Expressed at low levels in kidney.
Background: Phosphate-regulating neutral endopeptidase, X-linked also known as phosphate-regulating gene with homologies to endopeptidases on the X chromosome or metalloendopeptidase homolog PEX is an enzyme that in humans is encoded by the PHEX gene. It is mapped to Xp22.11. The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants.
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分子量
- 86 kDa
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基因ID
- 5251
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UniProt
- P78562
抗原
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