AIM2 抗体 (AA 136-354)
Quick Overview for AIM2 抗体 (AA 136-354) (ABIN7599984)
抗原
See all AIM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 136-354
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原理
- Anti-Aim2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Aim2 Antibody Picoband® (ABIN7599984). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse Aim2 recombinant protein (Position: Q136-E354).
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亚型
- IgG
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anti-Absent in Melanoma 2 (AIM2) (AA 1-195) antibody
AIM2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3C4G11 unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 1-195) antibodyAIM2 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 7G12D1 unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 1-343) antibodyAIM2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 1-50) antibodyAIM2 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 81-326) antibodyAIM2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 1-343) antibodyAIM2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 1-343) antibodyAIM2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (Internal Region) antibodyAIM2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 1-260) antibodyAIM2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Absent in Melanoma 2 (AIM2) (AA 14-215) antibodyAIM2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, Meltzer PS, Trent JM (Aug 1997). "Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma". Oncogene 15 (4): 453-7. 2. "Entrez Gene: AIM2 absent in melanoma 2". 3. Woerner SM, Kloor M, Schwitalle Y, Youmans H, von Knebel Doeberitz M, Gebert J, Dihlmann S (2007). "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers". Genes Chromosomes Cancer 46 (12): 1080-9. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- AIM2 (Absent in Melanoma 2 (AIM2))
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别名
- Aim2
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背景
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Synonyms: Coagulation factor V, Activated protein C cofactor, Proaccelerin, labile factor, Coagulation factor V heavy chain, Coagulation factor V light chain, F5
Tissue Specificity: Plasma.
Background: Interferon-inducible protein AIM2,also known asabsent in melanoma 2or simplyAIM2,is aproteinthat in humans is encoded by theAIM2gene. It is mapped to 1q22. AIM2 is a member of theIfi202/IFI16family. It plays a putative role in tumorigenic reversion and may control cell proliferation.Interferon-gammainduces expression of AIM2. Though there has been virtually no biochemistry performed, a model based on cell-based or in vivo experiments has led to the current model of how AIM2 triggers the inflammasome. The C-terminal HIN domain binds double stranded DNA(either viral, bacterial, or even host) and acts as a cytosolic dsDNA sensor. This leads to the oligomerization of the inflammasome complex. The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another proteinASC(or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain). ASC also contains aCARD domain(caspase activation and recruitment domain), that recruits procaspase-1 to the complex. This leads to the autoactivation ofcaspase-1, an enzyme that processes proinflammatorycytokines(IL-1bandIL-18).
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分子量
- 39 kDa
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基因ID
- 383619
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途径
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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