TTC39B 抗体 (AA 129-682)
Quick Overview for TTC39B 抗体 (AA 129-682) (ABIN7599918)
抗原
See all TTC39B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 129-682
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原理
- Anti-TTC39B Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-TTC39B Antibody Picoband® (ABIN7599918). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human TTC39B recombinant protein (Position: K129-D682).
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亚型
- IgG
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anti-Tetratricopeptide Repeat Domain 39B (TTC39B) (AA 625-654), (C-Term) antibody
TTC39B 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB27799 unconjugated
anti-Tetratricopeptide Repeat Domain 39B (TTC39B) (AA 10-122) antibodyTTC39B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tetratricopeptide Repeat Domain 39B (TTC39B) (AA 1-616) antibodyTTC39B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tetratricopeptide Repeat Domain 39B (TTC39B) (AA 378-427) antibodyTTC39B 适用: 人, Cow, 犬, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Tetratricopeptide Repeat Domain 39B (TTC39B) (AA 559-588), (C-Term) antibodyTTC39B 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hartz, P. A. Personal Communication. Baltimore, Md. 10/1/2010. 2. Hsieh, J., Koseki, M., Molusky, M. M., Yakushiji, E., Ichi, I., Westerterp, M., Iqbal, J., Chan, R. B., Abramowicz, S., Tascau, L., Takiguchi, S., Yamashita, S., Welch, C. L., Di Paolo, G., Hussain, M. M., Lefkowitch, J. H., Rader, D. J., Tall, A. R. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature 535: 303-307, 2016. 3. Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., Johansen, C. T., Fouchier, S. W., and 197 others. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466: 707-713, 2010. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))
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别名
- TTC39B
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背景
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Synonyms: RNA-binding protein 47,RNA-binding motif protein 47,RBM47,
Tissue Specificity: Abundantly expressed in tonsil, lymph node, and trachea, strong expression in prostate, lower expression in thyroid, stomach, and colon. .
Background: Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B protein contains two TPR repeats (aa 39 3-426 and 626 -659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LX R protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficiency mice display higher levels of HDL and Apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis.However it does not affect glucose tolerance or hepatic gluconeogenesis.
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分子量
- 70 kDa
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基因ID
- 158219
抗原
-
