Utrophin 抗体 (AA 1211-2294)
Quick Overview for Utrophin 抗体 (AA 1211-2294) (ABIN7599842)
抗原
See all Utrophin (UTRN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1211-2294
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原理
- Anti-Utrophin/UTRN Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Utrophin/UTRN Antibody Picoband® (ABIN7599842). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).
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亚型
- IgG
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anti-Utrophin (UTRN) (AA 1-252) antibody
UTRN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Utrophin (UTRN) (AA 3328-3433) antibodyUTRN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-Utrophin (UTRN) antibodyUTRN 适用: 人 IHC 宿主: 小鼠 Monoclonal DRP3-20C5 unconjugated
anti-Utrophin (UTRN) (AA 3328-3433) antibodyUTRN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Blake, D. J., Love, D. R., Tinsley, J., Morris, G. E., Turley, H., Gatter, K., Dickson, G., Edwards, Y. H., Davies, K. E. Characterization of a 4.8kb transcript from the Duchenne muscular dystrophy locus expressed in schwannoma cells. Hum. Molec. Genet. 1: 103-109, 1992. 2. Blake, D. J., Schofield, J. N., Zuellig, R. A., Gorecki, D. C., Phelps, S. R., Barnard, E. A., Edwards, Y. H., Davies, K. E. G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain. Proc. Nat. Acad. Sci. 92: 3697-3701, 1995. 3. Buckle, V. J., Guenet, J. L., Simon-Chazottes, D., Love, D. R., Davies, K. E. Localisation of a dystrophin-related autosomal gene to 6q24 in man, and to mouse chromosome 10 in the region of the dystrophia muscularis (dy) locus. Hum. Genet. 85: 324-326, 1990. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Utrophin (UTRN)
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别名
- UTRN
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背景
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Synonyms: Frizzled-4, Fz-4, hFz4, FzE4, CD344, FZD4
Tissue Specificity: Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.
Background: Utrophin is a protein that in humans is encoded by the UTRN gene. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described, however, the full-length nature of these variants has not yet been determined.
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分子量
- 394 kDa
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基因ID
- 7402
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UniProt
- P46939
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途径
- Skeletal Muscle Fiber Development
抗原
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