HDC 抗体 (AA 12-662)
Quick Overview for HDC 抗体 (AA 12-662) (ABIN7599827)
抗原
See all HDC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 12-662
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原理
- Anti-Histidine decarboxylase/HDC Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Histidine decarboxylase/HDC Antibody Picoband® (ABIN7599827). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Histidine decarboxylase/HDC recombinant protein (Position: R12-V662).
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亚型
- IgG
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anti-Histidine Decarboxylase (HDC) (AA 160-369) antibody
HDC 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (Internal Region) antibodyHDC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 341-597) antibodyHDC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 504-648) antibodyHDC 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 351-450) antibodyHDC 适用: 人, 小鼠 ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 365-643) antibodyHDC 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 449-462) antibodyVerified HDC 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 147-178) antibodyHDC 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histidine Decarboxylase (HDC) (AA 453-662) antibodyHDC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Bruneau, G., Nguyen, V. C., Gros, F., Bernheim, A., Thibault, J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum. Genet. 90: 235-238, 1992. 2. Dere, E., De Souza-Silva, M. A., Spieler, R. E., Lin, J. S., Ohtsu, H., Haas, H. L., Huston, J. P. Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5-HT turnover in histidine decarboxylase-KO mice.Europ. J. Neurosci. 20: 1051-1058, 2004. 3. Ercan-Sencicek, A. G., Stillman, A. A., Ghosh, A. K., Bilguvar, K., O'Roak, B. J., Mason, C. E., Abbott, T., Gupta, A., King, R. A., Pauls, D. L., Tischfield, J. A., Heiman, G. A., and 16 others. L-histidine decarboxylase and Tourette's syndrome. New Eng. J. Med. 362: 1901-1908, 2010. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- HDC (Histidine Decarboxylase (HDC))
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别名
- HDC
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背景
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Synonyms: Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43
Tissue Specificity: Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin.
Background: HDC(Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.
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分子量
- 74 kDa
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基因ID
- 3067
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UniProt
- P19113
抗原
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