SLFN11 抗体 (AA 114-794)
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- 抗原 See all SLFN11 products
- SLFN11 (Schlafen Family Member 11 (SLFN11))
- 抗原表位
- AA 114-794
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SLFN11 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
- 原理
- Anti-SLFN11 Antibody Picoband®
- 交叉反应 （详细）
- No cross-reactivity with other proteins.
- 产品特性
- Anti-SLFN11 Antibody Picoband® (ABIN7599761). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human SLFN11 recombinant protein (Position: P114-D794).
- 亚型
- IgG
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anti-Schlafen Family Member 11 (SLFN11) (AA 670-821) antibody
SLFN11 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Schlafen Family Member 11 (SLFN11) antibodySLFN11 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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- 应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bustos, O., Naik, S., Ayers, G., Casola, C., Perez-Lamigueiro, M. A., Chippindale, P. T., Pritham, E. J., de la Casa-Esperon, E. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes, and orthopoxvirus virulence. Gene 447: 1-11, 2009. 2. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H. E., Zerrahn, J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immun. 16: 1535-1548, 2004. 3. Gross, M. B. Personal Communication. Baltimore, Md. 11/29/2012. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- 抗原
- SLFN11 (Schlafen Family Member 11 (SLFN11))
- 别名
- SLFN11 (SLFN11 产品)
- 背景
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Synonyms: Neuropeptides B/W receptor type 1, G-protein coupled receptor 7, NPBWR1, GPR7
Tissue Specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea, at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
Background: Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.
- 分子量
- 103 kDa
- 基因ID
- 91607
- UniProt
- Q7Z7L1
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