TBC1D4 抗体 (AA 1118-1298)
Quick Overview for TBC1D4 抗体 (AA 1118-1298) (ABIN7599745)
抗原
See all TBC1D4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1118-1298
-
原理
- Anti-AS160/TBC1D4 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-/TBC1D4 Antibody Picoband® (ABIN7599745). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human TBC1D4 recombinant protein (Position: K1118-P1298).
-
亚型
- IgG
-
-
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 574-712) antibody
TBC1D4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 8A11A2 unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1-94) antibodyTBC1D4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) antibodyTBC1D4 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (Internal Region) antibodyVerified TBC1D4 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 172-201), (N-Term) antibodyTBC1D4 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21034 unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pSer642) antibodyTBC1D4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pThr642) antibodyTBC1D4 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1155-1204) antibodyTBC1D4 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pThr642) antibodyTBC1D4 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pSer588) antibodyTBC1D4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. "Entrez Gene: TBC1D4 TBC1 domain family, member 4". 2. Kurihara LJ, Semenova E, Miller W, Ingram RS, Guan XJ, Tilghman SM (Feb 2002). "Candidate genes required for embryonic development: a comparative analysis of distal mouse chromosome 14 and human chromosome 13q22".Genomics 79 (2): 154-61. 3. Sakamoto K, Holman GD (2008). "Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic". Am. J. Physiol. Endocrinol. Metab. 295 (1): E29-37. doi:10.1152/ajpendo.90331.2008. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))
-
别名
- TBC1D4
-
背景
-
Synonyms: Bifunctional epoxide hydrolase 2,Cytosolic epoxide hydrolase 2,CEH,3.3.2.10,Epoxide hydratase,Soluble epoxide hydrolase,SEH,Lipid-phosphate phosphatase,3.1.3.76,EPHX2,
Tissue Specificity: Ubiquitous. A high level expression is seen in secretory tissues.
Background: AS160 (Akt substrate of 160 kDa), which was originally known asTBC1 domain family member 4 (TBC1D4),is a RabGTPase-activatingproteinthat in humans is encoded by theTBC1D4gene. This gene is a member of the Tre-2/BUB2/CDC16 domain family. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion.
-
分子量
- 160 kDa
-
基因ID
- 9882
-
UniProt
- O60343
抗原
-
