L3MBTL3 抗体 (AA 11-686)
Quick Overview for L3MBTL3 抗体 (AA 11-686) (ABIN7599730)
抗原
See all L3MBTL3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-686
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原理
- Anti-L3MBTL3 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-L3MBTL3 Antibody Picoband® (ABIN7599730). Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human L3MBTL3 recombinant protein (Position: Q11-R686).
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亚型
- IgG
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anti-L(3)mbt-Like 3 (L3MBTL3) (AA 1-755) antibody
L3MBTL3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-L(3)mbt-Like 3 (L3MBTL3) (AA 1-230) antibodyL3MBTL3 适用: 人 WB, IP, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 3 (L3MBTL3) antibodyL3MBTL3 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 3 (L3MBTL3) (N-Term) antibodyL3MBTL3 适用: 人, 小鼠, Cow, Pig, 兔, 大鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 3 (L3MBTL3) antibodyL3MBTL3 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Arai, S., Miyazaki, T. Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J. 24: 1863-1873, 2005. 2. Xu, T., Park, S.-S., Giaimo, B. D., Hall, D., Ferrante, F., Ho, D. M., Hori, K., Anhezini, L., Ertl, I., Bartkuhn, M., Zhang, H., Milon, E., and 15 others. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J. 36: 3232-3249, 2017. 3. Zhang, C., Leng, F., Saxena, L., Hoang, N., Yu, J., Alejo, S., Lee, L., Qi, D., Lu, F., Sun, H., Zhang, H. Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase. J. Biol. Chem. 294: 476-489, 2019. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- L3MBTL3 (L(3)mbt-Like 3 (L3MBTL3))
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别名
- L3MBTL3
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背景
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Synonyms: RNA-binding protein Nova-2, Astrocytic NOVA1-like RNA-binding protein, Neuro-oncological ventral antigen 2, NOVA2, ANOVA, NOVA3
Tissue Specificity: Brain. Expression restricted to astrocytes.
Background: This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma.
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分子量
- 90 kDa
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基因ID
- 84456
抗原
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