Neurogranin 抗体 (AA 11-54)
Quick Overview for Neurogranin 抗体 (AA 11-54) (ABIN7599728)
抗原
See all Neurogranin (NRGN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-54
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原理
- Anti-Neurogranin/NRGN Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Neurogranin/NRGN Antibody Picoband® (ABIN7599728). Tested in ELISA, Flow Cytometry, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human NRGN recombinant protein (Position: K11-K54).
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亚型
- IgG
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anti-Neurogranin (NRGN) (Internal Region) antibody
Verified NRGN 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neurogranin (NRGN) (AA 1-67) antibodyNRGN 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Neurogranin (NRGN) (AA 30-78) antibodyNRGN 适用: 小鼠, 大鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neurogranin (NRGN) antibodyNRGN 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurogranin (NRGN) (AA 49-81), (C-Term) antibodyNRGN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB53232 unconjugated
anti-Neurogranin (NRGN) (Internal Region) antibody (Biotin)Verified NRGN 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal Biotin
anti-Neurogranin (NRGN) antibodyNRGN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurogranin (NRGN) (AA 1-78) antibodyNRGN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. characterization of a brain-specific protein kinase C substrate, neurogranin (p17): identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain. J. Biol. Chem. 266: 229-237, 1991. 2. Martinez de Arrieta, C., Morte, B., Coloma, A., Bernal, J. The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron. Endocrinology 140: 335-343, 1999. 3. Martinez de Arrieta, C., Perez Jurado, L., Bernal, J., Coloma, A. Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN). Genomics 41: 243-249, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Neurogranin (NRGN)
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别名
- NRGN
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背景
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Synonyms: Protein phosphatase 1 regulatory subunit 14A,17 kDa PKC-potentiated inhibitory protein of PP1,Protein kinase C-potentiated inhibitor protein of 17 kDa,CPI-17,PPP1R14A,CPI17, PPP1INL,
Tissue Specificity: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .
Background: Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
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分子量
- 11 kDa
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基因ID
- 4900
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UniProt
- Q92686
抗原
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