PDE6A 抗体 (AA 11-237)
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- 抗原 See all PDE6A 抗体
- PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
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抗原表位
- AA 11-237
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PDE6A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
- 原理
- Anti-PDE6 alpha/PDE6A Antibody Picoband®
- 交叉反应 （详细）
- No cross-reactivity with other proteins.
- 产品特性
- Anti-PDE6 alpha/PDE6A Antibody Picoband® (ABIN7599710). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human PDE6 alpha/PDE6A recombinant protein (Position: K11-R237).
- 亚型
- IgG
- Top Product
- Discover our top product PDE6A Primary Antibody
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anti-phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) (AA 656-860) antibody
PDE6A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) (AA 656-860) antibodyPDE6A 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) antibodyPDE6A 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) (N-Term) antibodyPDE6A 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blot, 0.1-0.25 μg/mL,Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 4 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Corton, M., Blanco, M. J., Torres, M., Sanchez-Salorio, M., Carracedo, A., Brion, M. Identification of a novel mutation in the human PDE6A gene in autosomal recessive retinitis pigmentosa: homology with the nmf28/nmf28 mice model. (Letter) Clin. Genet. 78: 495-498, 2010. 2. Khan, S. Y., Ali, S., Naeem, M. A., Khan, S. N., Husnain, T., Butt, N. H., Qazi, Z. A., Akram, J., Riazuddin, S., Ayyagari, R., Hejtmancik, J. F., Riazuddin, S. A. Splice-site mutations identified in PDE6A responsible for retinitis pigmentosa in consanguineous Pakistani families. Molec. Vision 21: 871-882, 2015. 3. Tuntivanich, N., Pittler, S. J., Fischer, A. J., Omar, G., Kiupel, M., Weber, A., Yao, S., Steibel, J. P., Khan, N. W., Petersen-Jones, S. M. Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation. Invest. Ophthal. Vis. Sci. 50: 801-813, 2009. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- 抗原
- PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
- 别名
- PDE6A (PDE6A 产品)
- 背景
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Synonyms: Protein SOX-15, Protein SOX-12, Protein SOX-20, SOX15, SOX12, SOX20, SOX26, SOX27
Tissue Specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
Background: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
- 分子量
- 100 kDa
- 基因ID
- 5145
- UniProt
- P16499
- 途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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