PYCR2 抗体 (AA 10-320)
Quick Overview for PYCR2 抗体 (AA 10-320) (ABIN7599597)
抗原
See all PYCR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 10-320
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原理
- Anti-PYCR2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PYCR2 Antibody Picoband® (ABIN7599597). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PYCR2 recombinant protein (Position: Q10-D320).
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亚型
- IgG
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anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) (AA 271-320) antibody
PYCR2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) antibodyPYCR2 适用: 人, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 2A5 unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) antibodyPYCR2 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) (AA 1-320) antibodyPYCR2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) (C-Term) antibodyPYCR2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) (AA 2-320) antibodyPYCR2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) antibodyPYCR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) antibodyPYCR2 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 2F11 unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) (AA 218-267) antibodyPYCR2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 猴, Pig, 斑马鱼, Hamster, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2) (AA 1-320) antibodyPYCR2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. De Ingeniis, J., Ratnikov, B., Richardson, A. D., Scott, D. A., Aza-Blanc, P., De, S. K., Kazanov, M., Pellecchia, M., Ronai, Z., Osterman, A. L., Smith, J. W. Functional specialization in proline biosynthesis of melanoma. PLoS One 7: e45190, 2012. Note: Electronic Article. 2. Escande-Beillard, N., Loh, A., Saleem, S. N., Kanata, K., Hashimoto, Y., Altunoglu, U., Metoska, A., Grandjean, J., Ng, F. M., Pomp, O., Baburajendran, N., Wong, J., Hill, J., Beillard, E., Cozzone, P., Zaki, M., Kayserili, H., Hamada, H., Shiratori, H., Reversade, B. Loss of PYCR2 causes neurodegeneration by increasing cerebral glycine levels via SHMT2. Neuron 107: 82-94, 2020. 3. Nakayama, T., Al-Maawali, A., El-Quessny, M., Rajab, A., Khalil, S., Stoler, J. M., Tan, W.-H., Nasir, R., Schmitz-Abe, K., Hill, R. S., Partlow, J. N., Al-Saffar, M., and 10 others. Mutations in PYCR2, encoding pyrroline-5-carboxylate reductase 2, cause microcephaly and hypomyelination. Am. J. Hum. Genet. 96: 709-719, 2015. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- PYCR2 (Pyrroline-5-Carboxylate Reductase Family, Member 2 (PYCR2))
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别名
- PYCR2
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背景
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Synonyms: Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA
Tissue Specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.
Background: Pyrroline-5-carboxylate reductase family, member 2 is a protein that in humans is encoded by the PYCR2 gene. This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.
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分子量
- 35 kDa
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基因ID
- 29920
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UniProt
- Q96C36
抗原
-
