OCRL 抗体 (AA 1-901)
Quick Overview for OCRL 抗体 (AA 1-901) (ABIN7599572)
抗原
See all OCRL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-901
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原理
- Anti-OCRL Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-OCRL Antibody Picoband® (ABIN7599572). Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human OCRL recombinant protein (Position: M1-D901).
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亚型
- IgG
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anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-239) antibody
OCRL 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 4A6 unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (C-Term) antibodyOCRL 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-240) antibodyOCRL 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 4A6 unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 121-271) antibodyOCRL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-240) antibodyOCRL 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4A6 unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (Internal Region) antibodyOCRL 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 1-893) antibodyOCRL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 1-893) antibodyOCRL 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (C-Term) antibodyOCRL 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Attree, O., Olivos, I. M., Okabe, I., Bailey, L. C., Nelson, D. L., Lewis, R. A., McInnes, R. R., Nussbaum, R. L. The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase. Nature 358: 239-242, 1992. 2. Bailey, L. C., Jr., Olivos, I. M., Leahey, A. M., Attree, O. F., Okabe, I., Lewis, R. A., MacInnes, R. R., Spinner, N. B., Nelson, D. L., Nussbaum, R. L. Characterization of a candidate gene for OCRL. (Abstract) Am. J. Hum. Genet. 51 (suppl.): A4 only, 1992. 3. Bockenhauer, D., Bokenkamp, A., Nuutinen, M., Unwin, R., van't Hoff, W., Sirimanna, T., Vrljicak, K., Ludwig, M. Novel OCRL mutations in patients with Dent-2 disease. J. Pediat. Genet. 1: 15-23, 2012. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))
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别名
- OCRL
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背景
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Synonyms: G2/mitotic-specific cyclin-B2, CCNB2
Tissue Specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
Background: Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the OCRL gene located on the X chromosome in humans. This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants.
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分子量
- 104 kDa
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基因ID
- 4952
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UniProt
- Q01968
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途径
- Inositol Metabolic Process
抗原
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