TMPRSS6 抗体 (AA 1-759)
Quick Overview for TMPRSS6 抗体 (AA 1-759) (ABIN7599541)
抗原
See all TMPRSS6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-759
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原理
- Anti-Matriptase 2/TMPRSS6 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Matriptase 2/TMPRSS6 Antibody Picoband® (ABIN7599541). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Matriptase 2/TMPRSS6 recombinant protein (Position: M1-Q759).
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亚型
- IgG
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anti-Transmembrane Protease, serine 6 (TMPRSS6) (AA 98-301) antibody
TMPRSS6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 6 (TMPRSS6) (AA 85-114), (N-Term) antibodyTMPRSS6 适用: 人 WB 宿主: 兔 Polyclonal RB39227 unconjugated
anti-Transmembrane Protease, serine 6 (TMPRSS6) (AA 71-120) antibodyTMPRSS6 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 6 (TMPRSS6) (AA 711-811) antibodyTMPRSS6 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, serine 6 (TMPRSS6) (AA 1-461) antibodyTMPRSS6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092, 2008. 2. Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydinok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., Andrews, N. C., Fleming, M. D. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nature Genet. 40: 569-571, 2008. 3. Guillem, F., Kannengiesser, C., Oudin, C., Lenoir, A., Matak, P., Donadieu, J., Isidor, B., Mechinaud, F., Aguilar-Martinez, P., Beaumont, C., Vaulont, S., Grandchamp, B., Nicolas, G. Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity. Hum. Mutat. 33: 1388-1396, 2012. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
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别名
- TMPRSS6
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背景
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Synonyms: Protein sprouty homolog 2, Spry-2, SPRY2
Tissue Specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Background: Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants.
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分子量
- 90 kDa, 95 kDa
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基因ID
- 164656
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途径
- Transition Metal Ion Homeostasis
抗原
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