HAP1 抗体 (AA 1-671)
Quick Overview for HAP1 抗体 (AA 1-671) (ABIN7599522)
抗原
See all HAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-671
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原理
- Anti-HAP1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-HAP1 Antibody Picoband® (ABIN7599522). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human HAP1 recombinant protein (Position: M1-R671).
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亚型
- IgG
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anti-Huntingtin Associated Protein 1 (HAP1) (Internal Region) antibody
Verified HAP1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 132-328) antibodyHAP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 328-580) antibodyHAP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (C-Term) antibodyVerified HAP1 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 160-381) antibodyHAP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 349-584) antibodyHAP1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) antibodyHAP1 适用: 大鼠 WB, IHC, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (Center) antibodyHAP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bertaux, F., Sharp, A. H., Ross, C. A., Lehrach, H., Bates, G. P., Wanker, E. HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. FEBS Lett. 426: 229-232, 1998. 2. Chan, E. Y. W., Nasir, J., Gutekunst, C.-A., Coleman, S., Maclean, A., Maas, A., Metzler, M., Gertsenstein, M., Ross, C. A., Nagy, A., Hayden, M. R. Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Hum. Molec. Genet. 11: 945-959, 2002. 3. Dragatsis, I., Zeitlin, S., Dietrich, P. Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation. Hum. Molec. Genet. 13: 3115-3125, 2004. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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别名
- HAP1
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背景
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Synonyms: Deoxycytidine kinase, dCK, DCK,
Tissue Specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
Background: Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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分子量
- 80 kDa
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基因ID
- 9001
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UniProt
- P54257
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途径
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
抗原
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