ZBTB48 抗体 (AA 1-623)
Quick Overview for ZBTB48 抗体 (AA 1-623) (ABIN7599504)
抗原
See all ZBTB48 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-623
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原理
- Anti-ZBTB48 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-ZBTB48 Antibody Picoband® (ABIN7599504). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ZBTB48 recombinant protein (Position: M1-M623).
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亚型
- IgG
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anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (AA 1-280) antibody
ZBTB48 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (AA 1-688) antibodyZBTB48 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (N-Term) antibodyZBTB48 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (AA 1-280) antibodyZBTB48 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (N-Term) antibodyZBTB48 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (AA 468-517) antibodyZBTB48 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠, Cow, 猴, Bat, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (AA 144-193) antibodyZBTB48 适用: 人, 犬, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 48 (ZBTB48) (N-Term) antibodyZBTB48 适用: 人, 小鼠, 大鼠, 犬, Cow, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Li, J. S. Z., Miralles Fuste, J., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Denchi, E. L. TZAP: a telomere-associated protein involved in telomere length control. Science 355: 638-641, 2017. 2. Maris, J. M., Jensen, S. J., Sulman, E. P., Beltinger, C. P., Gates, K., Allen, C., Biegel, J. A., Brodeur, G. M., White, P. S. Cloning, chromosomal localization, physical mapping, and genomic characterization of HKR3. Genomics 35: 289-298, 1996. 3. Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H. N., O'Brien, S. J., Vogelstein, B. The GLI-Kruppel family of human genes. Molec. Cell Biol. 8: 3104-3113, 1988 -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- ZBTB48 (Zinc Finger and BTB Domain Containing 48 (ZBTB48))
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别名
- ZBTB48
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背景
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Synonyms: RNA-binding protein 47,RNA-binding motif protein 47,RBM47,
Tissue Specificity: Abundantly expressed in tonsil, lymph node, and trachea, strong expression in prostate, lower expression in thyroid, stomach, and colon. .
Background: Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that ly binds to the double-stranded repeat sequence of telomeres. In humans it is encoded by the ZBTB48 gene. ZBTB48, also named as TZAP and HKR3, is a 688 amino acid protein, which contains 1 BTB (POZ) domain and 11 C2H2-type zinc fingers and belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB48 is detected in adrenal gland and neuroblastoma. ZBTB48 binds to and regulates the J and/or S elements in MHC II promoter. Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that triggers the trimming of telomeres in the absence of shelterin. ZBTB48, is a relatively uncharacterized POK family protein with a POZ-domain and 11 zinc finger domains. ZBTB48, is ubiquitously expressed in human tissues. The ZBTB48 gene is mapped to human chromosome 1p36, which is commonly rearranged (leiomyoma and leukemias) or deleted in various cancers (neuroblastoma, melanoma, Merkel cell carcinomas, pheochromocytoma and breast and colon carcinomas. A correlation between deletions or rearrangements of HKR3 and human cancer suggest a role for ZBTB48 as a potential tumor suppressor.
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分子量
- 77 kDa
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基因ID
- 3104
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UniProt
- P10074
抗原
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