SMTNL2 抗体 (AA 1-440)
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- 抗原 See all SMTNL2 products
- SMTNL2 (Smoothelin-Like 2 (SMTNL2))
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抗原表位
- AA 1-440
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMTNL2 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 原理
- Anti-SMTNL2 Antibody Picoband®
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
- Anti-SMTNL2 Antibody Picoband® (ABIN7599396). Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human SMTNL2 recombinant protein (Position: M1-K440). Human SMTNL2 shares 83.2% amino acid (aa) sequence identity with mouse SMTNL2.
- 亚型
- IgG
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anti-Smoothelin-Like 2 (SMTNL2) (AA 21-48), (N-Term) antibody
SMTNL2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB29222 unconjugated
anti-Smoothelin-Like 2 (SMTNL2) (AA 28-56), (N-Term) antibodySMTNL2 适用: 小鼠, 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Gordon, E. A., Whisenant, T. C., Zeller, M., Kaake, R. M., Gordon, W. M., Krotee, P., ... & Bardwell, L. (2013). Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. Cellular signalling, 25(12), 2518-2529. 2. Saxena, R., Plenge, R. M., Bjonnes, A. C., Dashti, H. S., Okada, Y., Gad El Haq, W., ... & Arayssi, T. (2017). A multinational Arab genome-wide association study identifies new genetic associations for rheumatoid arthritis. Arthritis & Rheumatology, 69(5), 976-985. 3. Hachimi, M., Grabowski, C., Campanario, S., Herranz, G., Baonza, G., Serrador, J. M., ... & Martin-Belmonte, F. (2021). Smoothelin-like 2 inhibits coronin-1B to stabilize the apical actin cortex during epithelial morphogenesis. Current Biology, 31(4), 696-706. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- 抗原
- SMTNL2 (Smoothelin-Like 2 (SMTNL2))
- 别名
- SMTNL2 (SMTNL2 产品)
- 背景
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Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity: Expressed in all tissues.
Background: The cytoskeletal protein smoothelin is highly conserved among vertebrates and is expressed exclusively by contractile smooth muscle cells where it localizes to the filament network. Smoothelin associates with Actin stress fibers but does not interact with Desmin. SMTNL2 (smoothelin-like 2), also known as FLJ42461, MGC131847 or MGC138382, is a 461 amino acid protein belonging to the smoothelin family. Containing a single CH (calponin-homology) domain, SMTNL2 is considered an Actin binding protein. SMTNL2 exists as two isoforms produced by alternative splicing events and is encoded by a gene mapping to human chromosome 17. Human chromosome 17 comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is ly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
- 分子量
- 50 kDa
- 基因ID
- 342527
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