DUSP6 抗体 (AA 1-381)
Quick Overview for DUSP6 抗体 (AA 1-381) (ABIN7599332)
抗原
See all DUSP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-381
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原理
- Anti-DUSP6 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-DUSP6 Antibody Picoband® (ABIN7599332). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human DUSP6 recombinant protein (Position: M1-T381).
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亚型
- IgG
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anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) antibody
DUSP6 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3G2 unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 1-300) antibodyDUSP6 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 58-89) antibodyDUSP6 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05814 unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 1-170) antibodyDUSP6 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 59-88) antibodyDUSP6 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 100-206) antibodyDUSP6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (AA 1-382) antibodyDUSP6 适用: 人 WB, ELISA, IHC, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3G2 unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (C-Term) antibodyDUSP6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) (Internal Region) antibodyDUSP6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dual Specificity Phosphatase 6 (DUSP6) antibodyDUSP6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Furukawa, T., Yatsuoka, T., Youssef, E. M., Abe, T., Yokoyama, T., Fukushige, S., Soeda, E., Hoshi, M., Hayashi, Y., Sunamura, M., Kobari, M., Horii, A. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. Cytogenet. Cell Genet. 82: 156-159, 1998. 2. Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S., Keyse, S. M. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J. 15: 3621-3632, 1996. 3. Maillet, M., Purcell, N. H., Sargent, M. A., York, A. J., Bueno, O. F., Molkentin, J. D. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J. Biol. Chem. 283: 31246-31255, 2008. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))
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别名
- DUSP6
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背景
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Synonyms: Sentrin-specific protease 1, Sentrin/SUMO-specific protease SENP1, SENP1
Tissue Specificity: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Background: Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
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分子量
- 50 kDa
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基因ID
- 1848
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UniProt
- Q16828
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途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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