SPRY2 抗体 (AA 1-315)
Quick Overview for SPRY2 抗体 (AA 1-315) (ABIN7599261)
抗原
See all SPRY2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-315
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原理
- Anti-Spry-2/SPRY2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Spry-2/SPRY2 Antibody Picoband® (ABIN7599261). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Spry-2/SPRY2 recombinant protein (Position: M1-T315).
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亚型
- IgG
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anti-Sprouty Homolog 2 (SPRY2) (AA 1-315) antibody
SPRY2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E10 unconjugated
anti-Sprouty Homolog 2 (SPRY2) (AA 2-97) antibodySPRY2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) antibodySPRY2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) (AA 107-156) antibodySPRY2 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) (AA 1-315) antibodySPRY2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) (AA 116-305) antibodySPRY2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) (AA 116-304) antibodySPRY2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) (N-Term) antibodySPRY2 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) antibodySPRY2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 2 (SPRY2) (AA 1-315) antibodySPRY2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Milillo, A., La Carpia, F., Costanzi, S., D'Urbano, V., Martini, M., Lanuti, P., Vischini, G., Larocca, L. M., Marchisio, M., Miscia, S., Amoroso, A., Gurrieri, F., Sangiorgi, E. A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy. Europ. J. Hum. Genet. 23: 1673-1678, 2015. 2. Shim, K., Minowada, G., Coling, D. E., Martin, G. R. Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev. Cell 8: 553-564, 2005. 3. Taketomi, T., Yoshiga, D., Taniguchi, K., Kobayashi, T., Nonami, A., Kato, R., Sasaki, M., Sasaki, A., Ishibashi, H., Moriyama, M., Nakamura, K., Nishimura, J., Yoshimura, A. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nature Neurosci. 8: 855-857, 2005. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SPRY2 (Sprouty Homolog 2 (SPRY2))
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别名
- SPRY2
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背景
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Synonyms: Protein sprouty homolog 2, Spry-2, SPRY2
Tissue Specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Background: Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene. It is mapped to 13q31.1. This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is inly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
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分子量
- 35 kDa
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基因ID
- 10253
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UniProt
- O43597
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途径
- EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation
抗原
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