RAD51AP1 抗体 (AA 1-303)
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- 抗原 See all RAD51AP1 抗体
- RAD51AP1 (RAD51-Interacting Protein (RAD51AP1))
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抗原表位
- AA 1-303
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RAD51AP1 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
- 原理
- Anti-RAD51AP1 Antibody Picoband®
- 产品特性
- Anti-RAD51AP1 Antibody Picoband® (ABIN7599248). Tested in WB, IF, IHC, ICC, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human RAD51AP1 recombinant protein (Position: M1-K303).
- Top Product
- Discover our top product RAD51AP1 Primary Antibody
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anti-RAD51-Interacting Protein (RAD51AP1) (AA 1-335) antibody
RAD51AP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-RAD51-Interacting Protein (RAD51AP1) (C-Term) antibodyVerified RAD51AP1 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-RAD51-Interacting Protein (RAD51AP1) (AA 1-335) antibodyRAD51AP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-RAD51-Interacting Protein (RAD51AP1) (Middle Region) antibodyRAD51AP1 适用: 人, 大鼠, 犬, 马, 兔, Pig, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Kovalenko, O. V., Golub, E. I., Bray-Ward, P., Ward, D. C., Radding, C. M. A novel nucleic acid-binding protein that interacts with human Rad51 recombinase. Nucleic Acids Res. 25: 4946-4953, 1997. 2. Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N., Jenkins, N. A., Lalande, M., Alt, F. W. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc. Nat. Acad. Sci. 94: 6927-6932, 1997. 3. Modesti, M., Budzowska, M., Baldeyron, C., Demmers, J. A. A., Ghirlando, R., Kanaar, R. RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Molec. Cell 28: 468-481, 2007. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- 抗原
- RAD51AP1 (RAD51-Interacting Protein (RAD51AP1))
- 别名
- RAD51AP1 (RAD51AP1 产品)
- 背景
- The RAD51AP1 gene encodes a protein known as RAD51-associated protein 1, which plays a crucial role in homologous recombination, a DNA repair pathway essential for maintaining genomic integrity. RAD51AP1 interacts with RAD51, a key protein involved in homologous recombination, and promotes the assembly of RAD51 nucleoprotein filaments on single-stranded DNA, facilitating the search for homologous sequences and strand exchange. This process is vital for repairing DNA double-strand breaks and stalled replication forks, as well as for meiotic recombination and telomere maintenance. Dysregulation of RAD51AP1 expression or function has been implicated in cancer development and progression, as defects in homologous recombination can lead to genomic instability and oncogenesis. Understanding the molecular mechanisms underlying RAD51AP1-mediated homologous recombination is crucial for deciphering its role in DNA repair and genome maintenance, as well as for developing targeted therapies for cancer and other diseases associated with DNA damage.
- 分子量
- 38 kDa
- 基因ID
- 10635
- UniProt
- Q96B01
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