PTF1A 抗体 (AA 1-292)
Quick Overview for PTF1A 抗体 (AA 1-292) (ABIN7599226)
抗原
See all PTF1A 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-292
-
原理
- Anti-PTF1A Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-PTF1A Antibody Picoband® (ABIN7599226). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human PTF1A recombinant protein (Position: M1-Q292).
-
亚型
- IgG
-
-
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 177-328) antibody
PTF1A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (Internal Region) antibodyVerified PTF1A 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 250-328) antibodyPTF1A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1A2 unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 224-325) antibodyPTF1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 12-43), (N-Term) antibodyPTF1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB10418 unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 12-43) antibodyPTF1A 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 250-328) antibodyPTF1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B8 unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (N-Term) antibodyPTF1A 适用: 人, 斑马鱼, 犬, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Pancreas Specific Transcription Factor, 1a (PTF1A) (AA 35-84) antibodyPTF1A 适用: 人, 小鼠, 马, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Al-Shammari, M., Al-Husain, M., Al-Kharfy, T., Alkuraya, F. S. A novel PTF1A mutation in a patient with severe pancreatic and cerebellar involvement. (Letter) Clin. Genet. 80: 196-198, 2011. 2. Sellick, G. S., Barker, K. T., Stolte-Dijkstra, I., Fleischmann, C., Coleman, R. J., Garrett, C., Gloyn, A. L., Edghill, E. L., Hattersley, A. T., Wellauer, P. K., Goodwin, G., Houlston, R. S. Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nature Genet. 36: 1301-1305, 2004. 3. Weedon, M. N., Cebola, I., Patch, A.-M., Flanagan, S. E., De Franco, E., Caswell, R., Rodriguez-Segui, S. A., Shaw-Smith, C., Cho, C. H.-H., Allen, H. L., Houghton, J. A. L., Roth, C. L., and 9 others. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nature Genet. 46: 61-64, 2014. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))
-
别名
- PTF1A
-
背景
-
Synonyms: Pancreas transcription factor 1 subunit alpha, Class A basic helix-loop-helix protein 29, bHLHa29, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1A, BHLHA29, PTF1P48
Tissue Specificity: Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
Background: Pancreas transcription factor 1 subunit alpha is a protein that in humans is encoded by the PTF1A gene. It is mapped to 10p12.2. This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
-
分子量
- 48 kDa
-
基因ID
- 256297
-
途径
- Retinoic Acid Receptor Signaling Pathway
抗原
-
