HAX1 抗体 (AA 1-279)
Quick Overview for HAX1 抗体 (AA 1-279) (ABIN7599208)
抗原
See all HAX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-279
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原理
- Anti-HAX1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-HAX1 Antibody Picoband® (ABIN7599208). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human HAX1 recombinant protein (Position: M1-R279).
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亚型
- IgG
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anti-HCLS1 Associated Protein X-1 (HAX1) antibody
HAX1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (AA 2-250) antibodyHAX1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (AA 76-174) antibodyHAX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D2 unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (AA 1-279) antibodyHAX1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (AA 1-279) antibodyHAX1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (C-Term) antibodyHAX1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) antibodyHAX1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (AA 191-279) antibodyHAX1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (Internal Region) antibodyVerified HAX1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-HCLS1 Associated Protein X-1 (HAX1) (AA 107-156) antibodyHAX1 适用: 人, 小鼠, 豚鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10^6 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Carlsson, G., Fasth, A. Infantile genetic agranulocytosis, morbus Kostmann: presentation of six cases from the original 'Kostmann family' and a review. Acta Paediat. 90: 757-764, 2001. 2. Chao, J.-R., Parganas, E., Boyd, K., Hong, C. Y., Opferman, J. T., Ihle, J. N. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature 452: 98-102, 2008. Note: Erratum: Nature 452: 900 only, 2008. 3. Dale, D. C., Person, R. E., Bolyard, A. A., Aprikyan, A. G., Bos, C., Bonilla, M. A., Boxer, L. A., Kannourakis, G., Zeidler, C., Welte, K., Benson, K. F., Horwitz, M. Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96: 2317-2322, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- HAX1 (HCLS1 Associated Protein X-1 (HAX1))
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别名
- HAX1
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背景
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Synonyms: Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, CDK8
Tissue Specificity: Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359). Low expression levels in the small intestine and colon (PubMed:11099417). Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359).
Background: HCLS1-associated protein X-1 is a protein that in humans is encoded by the HAX1 gene. The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
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分子量
- 36 kDa
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基因ID
- 10456
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UniProt
- O00165
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途径
- Regulation of Actin Filament Polymerization
抗原
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