SESN1 抗体 (AA 1-275)
Quick Overview for SESN1 抗体 (AA 1-275) (ABIN7599203)
抗原
See all SESN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-275
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原理
- Anti-SESN1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SESN1 Antibody Picoband® (ABIN7599203). Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SESN1 recombinant protein (Position: M1-A275).
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亚型
- IgG
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anti-Sestrin 1 (SESN1) (AA 1-551) antibody
SESN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) antibodySESN1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 224-337) antibodySESN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 271-370) antibodySESN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 1-551) antibodySESN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 312-341), (C-Term) antibodySESN1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB18601 unconjugated
anti-Sestrin 1 (SESN1) (AA 45-492) antibodySESN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 375-424) antibodySESN1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (C-Term) antibodySESN1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 14-43), (N-Term) antibodySESN1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB18600 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Buckbinder, L., Talbott, R., Seizinger, B. R., Kley, N. Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes. Proc. Nat. Acad. Sci. 91: 10640-10644, 1994. 2. Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., Chumakov, P. M. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596-600, 2004. 3. Cangelosi, A. L., Puszynska, A. M., Roberts, J. M., Armani, A., Nguyen, T. P., Spinelli, J. B., Kunchok, T., Wang, B., Chan, S. H., Lewis, C. A., Comb, W. C., Bell, G. W., Helman, A., Sabatini, D. M. Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science 377: 47-56, 2022. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SESN1 (Sestrin 1 (SESN1))
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别名
- SESN1
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背景
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Synonyms: Dynein light chain Tctex-type 1, Protein CW-1, T-complex testis-specific protein 1 homolog, DYNLT1, TCTEL1, TCTEX-1, TCTEX1
Tissue Specificity: Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).
Background: Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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分子量
- 56 kDa
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基因ID
- 27244
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UniProt
- Q9Y6P5
抗原
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