GRB14 抗体 (AA 1-246)
Quick Overview for GRB14 抗体 (AA 1-246) (ABIN7599149)
抗原
See all GRB14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-246
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原理
- Anti-GRB14 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GRB14 Antibody Picoband® (ABIN7599149). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GRB14 recombinant protein (Position: M1-Q246).
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 14 (GRB14) (AA 294-397) antibody
GRB14 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 14 (GRB14) (AA 14-48) antibodyGRB14 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB57897 unconjugated
anti-Growth Factor Receptor-Bound Protein 14 (GRB14) (Internal Region) antibodyGRB14 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 14 (GRB14) (AA 221-320) antibodyGRB14 适用: 人 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 14 (GRB14) antibodyGRB14 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 14 (GRB14) (Internal Region) antibodyGRB14 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 14 (GRB14) (AA 251-300) antibodyGRB14 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Daly, R. J., Sanderson, G. M., Janes, P. W., Sutherland, R. L. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J. Biol. Chem. 271: 12502-12510, 1996. 2. Depetris, R. S., Hu, J., Gimpelevich, I., Holt, L. J., Daly, R. J., Hubbard, S. R. Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Molec. Cell 20: 325-333, 2005. 3. Dong, L. Q., Du, H., Porter, S. G., Kolakowski, L. F., Jr., Lee, A. V., Mandarino, L. J., Fan, J., Yee, D., Liu, F. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10-gamma. J. Biol. Chem. 272: 29104-29112, 1997. Note: Erratum: J. Biol. Chem. 273: 4288 only, 1998. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))
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别名
- GRB14
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背景
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Synonyms: Endothelial cell-specific molecule 1, ESM-1, ESM1
Tissue Specificity: Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.
Background: Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants.
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分子量
- 61 kDa
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基因ID
- 2888
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UniProt
- Q14449
抗原
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