DOCK8 抗体 (AA 1-2099)
Quick Overview for DOCK8 抗体 (AA 1-2099) (ABIN7599085)
抗原
See all DOCK8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-2099
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原理
- Anti-DOCK8 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-DOCK8 Antibody Picoband® (ABIN7599085). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human DOCK8 recombinant protein (Position: M1-S2099). Human DOCK8 shares 91.8% amino acid (aa) sequence identity with mouse DOCK8.
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亚型
- IgG
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anti-Dedicator of Cytokinesis 8 (DOCK8) (AA 1900-2099) antibody
DOCK8 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dedicator of Cytokinesis 8 (DOCK8) (AA 833-1160) antibodyDOCK8 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 5C4 unconjugated
anti-Dedicator of Cytokinesis 8 (DOCK8) (AA 2056-2090) antibodyDOCK8 适用: 人 WB 宿主: 兔 Polyclonal RB54293 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL
1. Griggs, B. L., Ladd, S., Saul, R. A., DuPont, B. R., Srivastava, A. K. Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics 91: 195-202, 2008. 2. MacDermot, K. D., Hulten, M. Female with hypohidrotic ectodermal dysplasia and de novo (X,9) translocation: clinical documentation of the AnLy cell line case. Hum. Genet. 84: 577-579, 1990. 3. Pillay, B. A., Fusaro, M., Gray, P. E., Statham, A. L., Burnett, L., Bezrodnik, L., Kane, A., Tong, W., Abdo, C., Winter, S., Chevalier, S., Levy, R., and 18 others. Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency. J. Clin. Invest. 131: e142434, 2021. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))
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别名
- DOCK8
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背景
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Synonyms: DOCK8, Dedicator of cytokinesis protein 8
Background: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
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分子量
- 230 kDa
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基因ID
- 81704
抗原
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