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DOCK8 抗体 (AA 1-2099)

DOCK8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7599085
发货至: 中国
  • 抗原 See all DOCK8 抗体
    DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))
    抗原表位
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-2099
    适用
    人, 小鼠, 大鼠
    宿主
    • 5
    • 4
    克隆类型
    • 5
    • 4
    多克隆
    标记
    • 9
    This DOCK8 antibody is un-conjugated
    应用范围
    • 8
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    原理
    Anti-DOCK8 Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-DOCK8 Antibody Picoband® (ABIN7599085). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human DOCK8 recombinant protein (Position: M1-S2099). Human DOCK8 shares 91.8% amino acid (aa) sequence identity with mouse DOCK8.
    亚型
    IgG
    Top Product
    Discover our top product DOCK8 Primary Antibody
  • 应用备注
    Western blot, 0.25-0.5 μg/mL, Rat
    Immunohistochemistry, 2-5 μg/mL, Human, Mouse
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL
    1. Griggs, B. L., Ladd, S., Saul, R. A., DuPont, B. R., Srivastava, A. K. Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics 91: 195-202, 2008. 2. MacDermot, K. D., Hulten, M. Female with hypohidrotic ectodermal dysplasia and de novo (X,9) translocation: clinical documentation of the AnLy cell line case. Hum. Genet. 84: 577-579, 1990. 3. Pillay, B. A., Fusaro, M., Gray, P. E., Statham, A. L., Burnett, L., Bezrodnik, L., Kane, A., Tong, W., Abdo, C., Winter, S., Chevalier, S., Levy, R., and 18 others. Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency. J. Clin. Invest. 131: e142434, 2021.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    储存条件
    4 °C,-20 °C
    储存方法
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原
    DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))
    别名
    DOCK8 (DOCK8 产品)
    背景

    Synonyms: DOCK8, Dedicator of cytokinesis protein 8

    Background: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

    分子量
    230 kDa
    基因ID
    81704
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