Aconitase 1 抗体 (AA 1-137)
Quick Overview for Aconitase 1 抗体 (AA 1-137) (ABIN7598988)
抗原
See all Aconitase 1 (ACO1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-137
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原理
- Anti-Aconitase 1/ACO1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Aconitase 1/ACO1 Antibody Picoband® (ABIN7598988). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Aconitase 1/ACO1 recombinant protein (Position: M1-D137).
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亚型
- IgG
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anti-Aconitase 1 (ACO1) (AA 329-443) antibody
ACO1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 251-443) antibodyACO1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (N-Term) antibodyACO1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠, 马, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 26-243) antibodyACO1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 508-745) antibodyACO1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 1-889) antibodyACO1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 780-889) antibodyACO1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Aconitase 1 (ACO1) antibodyACO1 适用: 人, 小鼠, 大鼠, Hamster WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 527-719) antibodyACO1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (N-Term) antibodyACO1 适用: 人, 大鼠, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Monkey, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 4 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Azevedo, E. S., Da Silva, M. C. B. O., Lima, A. M. V., Fonseca, E. F., Conseicao, M. M. Human aconitase polymorphism in three samples from northeastern Brazil. Ann. Hum. Genet. 43: 7-10, 1979. 2. Condo, I., Malisan, F., Guccini, I., Serio, D., Rufini, A., Testi, R. Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin. Hum. Molec. Genet. 19: 1221-1229, 2010. 3. Eisenstein, R. S. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu. Rev. Nutr. 20: 627-662, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Aconitase 1 (ACO1)
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别名
- ACO1
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背景
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Synonyms: CD3 antigen, epsilon polypeptide, CD3e molecule, Cd3e, Cd3e_predicted, rCG_58471
Background: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.
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分子量
- 98 kDa
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基因ID
- 48
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UniProt
- P21399
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途径
- Transition Metal Ion Homeostasis
抗原
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