Fission 1 抗体 (AA 1-121)
Quick Overview for Fission 1 抗体 (AA 1-121) (ABIN7598965)
抗原
See all Fission 1 (FIS1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-121
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原理
- Anti-TTC11/FIS1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-TTC11/FIS1 Antibody (ABIN7598965). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human TTC11/FIS1 recombinant protein (Position: M1-D121).
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亚型
- IgG
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anti-Fission 1 (FIS1) (full length) antibody
FIS1 适用: 人, 小鼠, 大鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fission 1 (FIS1) (AA 1-117) antibodyFIS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fission 1 (FIS1) antibodyKO Validated FIS1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Fission 1 (FIS1) (AA 1-152) antibodyFIS1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G9 unconjugated
anti-Fission 1 (FIS1) (AA 1-122) antibodyFIS1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Fission 1 (FIS1) (AA 55-152) antibodyFIS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fission 1 (FIS1) (AA 1-122) antibodyFIS1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fission 1 (FIS1) (AA 6-40), (N-Term) antibodyFIS1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50047 unconjugated
anti-Fission 1 (FIS1) (AA 1-152) antibodyFIS1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Fission 1 (FIS1) (AA 1-100) antibodyFIS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C8 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Dohm, J. A., Lee, S. J., Hardwick, J. M., Hill, R. B., Gittis, A. G. Cytosolic domain of the human mitochondrial fission protein Fis1 adopts a TPR fold. Proteins 54: 153-156, 2004. 2. Frieden, M., James, D., Castelbou, C., Danckaert, A., Martinou, J.-C., Demaurex, N. Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J. Biol. Chem. 279: 22704-22714, 2004. 3. James, D. I., Parone, P. A., Mattenberger, Y., Martinou, J.-C. hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem. 278: 36373-36379, 2003. Note: Erratum: J. Biol. Chem. 279: 36166 only, 2004. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Fission 1 (FIS1)
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别名
- FIS1
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背景
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Synonyms: Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11, CGI-135
Tissue Specificity: Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Background: Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7. It is mapped to 7q22.1. The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission. Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell cycle, and apoptosis. By extension, the protein is involved in associated diseases, including neurodegenerative diseases and cancers.
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分子量
- 17 kDa
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基因ID
- 51024
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UniProt
- Q9Y3D6
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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