MERS-Coronavirus Spike 抗体 (AA 18-1296)
MERS-CoV S
适用: Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
ELISA
宿主: 小鼠
Monoclonal
AT25E4
unconjugated
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- 抗原 See all MERS-Coronavirus Spike (MERS-CoV S) products
- MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))
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抗原表位
- AA 18-1296
- 适用
- Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MERS-Coronavirus Spike antibody is un-conjugated
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应用范围
- ELISA
- 原理
- MERS-CoV Spike antibody
- 纯化方法
- protein-A affinity chromatography
- 免疫原
- Recombinant MERS-CoV Spike (18-1296aa) purified from Baculovirus
- 克隆位点
- AT25E4
- 亚型
- IgG1 kappa
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anti-MERS-Coronavirus Spike Protein (MERS-CoV S) (AA 381-505) antibody
MERS-CoV S 适用: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) WB 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
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- 抗原
- MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))
- 别名
- MERS-CoV Spike (MERS-CoV S 产品)
- 物质类
- Viral Protein
- 背景
- MERS-CoV, which causes the Middles East Respiratory Syndrome (MERS), belongs to a family of viruses known as coronaviruses. MERS-CoV was first identified in the Kingdom of Saudi Arabia in 2012, which is a single and positive stranded RNA virus. Dromedary camels are widely considered as the source of the transmission of MERS-CoV. The rate of human transmission among household contacts of MERS patients has been approximately 5 % based on serological analysis. MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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