MERS-Coronavirus Spike 抗体 (AA 18-1296)
This anti-MERS-Coronavirus Spike antibody is a 小鼠 单克隆 antibody detecting MERS-Coronavirus Spike in ELISA. Suitable for Middle East Respiratory Syndrome Coronavirus (MERS-CoV).
Quick Overview for MERS-Coronavirus Spike 抗体 (AA 18-1296) (ABIN7596098)
抗原
MERS-Coronavirus Spike (MERS-CoV S)
(MERS-Coronavirus Spike Protein (MERS-CoV S))
适用
Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
宿主
小鼠
克隆类型
单克隆
标记
This MERS-Coronavirus Spike antibody is un-conjugated
应用范围
ELISA
克隆位点
AT23D3
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抗原表位
- AA 18-1296
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原理
- MERS-CoV Spike antibody
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纯化方法
- protein-A affinity chromatography
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免疫原
- Recombinant MERS-CoV Spike (18-1296aa) purified from Baculovirus
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亚型
- IgG1 kappa
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anti-MERS-Coronavirus Spike Protein (MERS-CoV S) (AA 381-505) antibody
MERS-CoV S 适用: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) WB 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
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- MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))
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别名
- MERS-CoV Spike
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物质类
- Viral Protein
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背景
- MERS-CoV, which causes the Middles East Respiratory Syndrome (MERS), belongs to a family of viruses known as coronaviruses. MERS-CoV was first identified in the Kingdom of Saudi Arabia in 2012, which is a single and positive stranded RNA virus. Dromedary camels are widely considered as the source of the transmission of MERS-CoV. The rate of human transmission among household contacts of MERS patients has been approximately 5 % based on serological analysis. MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
抗原
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