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Lactate Dehydrogenase A 抗体 (AA 1-332)

This anti-Lactate Dehydrogenase A antibody is a 小鼠 单克隆 antibody detecting Lactate Dehydrogenase A in WB, ELISA, IF 和 ICC. Suitable for 人.
产品编号 ABIN7596077
发货至: 中国

Quick Overview for Lactate Dehydrogenase A 抗体 (AA 1-332) (ABIN7596077)

抗原

See all Lactate Dehydrogenase A (LDHA) 抗体
Lactate Dehydrogenase A (LDHA)

适用

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宿主

  • 102
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小鼠

克隆类型

  • 109
  • 22
单克隆

标记

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This Lactate Dehydrogenase A antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

克隆位点

AT1A4
  • 抗原表位

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    AA 1-332

    原理

    Human Lactate Dehydrogenase A/LDHA antibody

    纯化方法

    protein-A affinity chromatography

    免疫原

    Recombinant human LDHA (1-332aa) purified from E.coli

    亚型

    IgG2b kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
  • 抗原

    Lactate Dehydrogenase A (LDHA)

    别名

    Lactate Dehydrogenase A/LDHA

    背景

    Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.

    NCBI登录号

    NP_005557

    途径

    Warburg Effect
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