GRIK1 抗体 (AA 824-1203)
Quick Overview for GRIK1 抗体 (AA 824-1203) (ABIN7595945)
抗原
See all GRIK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 824-1203
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原理
- Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
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特异性
- Recognizes mGluR1 and mGluR5
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
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Description: Our Anti-mGluR1/5 (Group I) glutamate receptor mouse monoclonal primary antibody is produced in-house from hybridoma clone N75/33. It detects human, mouse, and rat mGluR1/5 (Group I) glutamate receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Manufacturer Comment: We produce our mGluR1/5 (Group I) glutamate receptor mouse monoclonal primary antibody from hybridoma clone N75/33. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.
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纯化方法
- Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.
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纯度
- > 90 % specific antibody
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免疫原
- Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (accession number P31424) produced recombinantly in E. Coli
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亚型
- IgG1
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anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 675-834) antibody
GRIK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (Internal Region) antibodyVerified GRIK1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (Extracellular) antibodyGRIK1 适用: 大鼠 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 331-440) antibodyGRIK1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 271-450) antibodyGRIK1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 10-59) antibodyGRIK1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (Center) antibodyGRIK1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (C-Term) antibodyGRIK1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.44
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
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有效期
- 24 months
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- GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))
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别名
- 5 glutamate receptor
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背景
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Synonyms: Metabotropic glutamate receptor 5 (mGluR5)
Target Description: The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).
Gene Name Alternatives: Grm5 Gprc1e Mglur5
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分子量
- 130 kDa (both mGluR1 and mGluR5)
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途径
- Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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