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SHANK2 抗体 (AA 84-309) (FL550)

This anti-SHANK2 antibody is a 小鼠 单克隆 antibody detecting SHANK2 in IHC 和 ICC. Suitable for 大鼠.
产品编号 ABIN7595603
发货至: 中国

Quick Overview for SHANK2 抗体 (AA 84-309) (FL550) (ABIN7595603)

抗原

See all SHANK2 抗体
SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

适用

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大鼠

宿主

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小鼠

克隆类型

  • 44
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单克隆

标记

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This SHANK2 antibody is conjugated to FL550

应用范围

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Immunohistochemistry (IHC), Immunocytochemistry (ICC)

克隆位点

N23B-6
  • 抗原表位

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    AA 84-309

    原理

    Anti-Shank2 Antibody FL550 Conjugate

    特异性

    No off-targets reported for Shank1 or Shank3

    交叉反应

    人, 小鼠, 兔, 大鼠

    产品特性

    Description: Our Anti-Shank2 mouse monoclonal primary antibody is produced in-house from hybridoma clone N23B/6. It detects human, mouse, and rat Shank2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

    Manufacturer Comment: We produce our Shank2 mouse monoclonal primary antibody from hybridoma clone N23B/6. It is great in IHC, ICC and is purified by Protein A chromatography.

    纯化方法

    Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

    纯度

    > 90 % specific antibody

    免疫原

    Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (accession number Q9QX74) produced recombinantly in E. Coli

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 mg/mL

    缓冲液

    PBS with 0.09 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

    有效期

    12 months
  • 抗原

    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

    别名

    Shank2

    背景

    Synonyms: SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3)

    Target Description: SH3 and multiple ankyrin repeat domains protein 2, or shank 2 is a member of the shank family. Shank 2 binding domains include a SH3 domain, a proline rich domain, and a PDZ domain. Shank 2 is found in kidney, liver tissue, and epithelial cells. In brain, Shank 2 is expressed at the apical cell membrane, cytoplasm, synapse, postsynaptic density, growth cone, and dendritic spine. Some isoforms of shank 2 are expressed during development, while others are expressed in mature tissue. Shank 2 acts as a scaffold protein anchoring and connecting membrane bound receptors, including NMDA and glutamate receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 2 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 2 gene have been associated with autism spectrm disorder and blount disease.

    Gene Name Alternatives: Shank2 Cortbp1

    分子量

    160 kDa
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