Neuraminidase 抗体
NA
适用: Influenza A Virus
WB, ELISA, IHC
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all Neuraminidase (NA) products
- Neuraminidase (NA)
- 适用
- Influenza A Virus
- Virus Strain
- A/Chicken/Scotland/1959
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Neuraminidase antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 原理
- Rabbit antibody to Influenza A virus Neuraminidase (40...390)
- 特异性
- Specific for Influenza A virus NA.
- 交叉反应
- Influenza A Virus
- 纯化方法
- Purified IgG
- 免疫原
- A chimeric recombinant Neuraminidase from Influenza A virus NA (strain A/Chicken/Scotland/1959 H5N1) containing regions 40-80 140-175 190-230 245-278 and 361-390 was used as the antigen.
- 亚型
- IgG
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- 应用备注
- IHC WB ELISA. A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8C for a shorter term.
- 有效期
- 12 months
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- 抗原
- Neuraminidase (NA)
- 别名
- Neuraminidase (NA 产品)
- 物质类
- Influenza Protein
- 背景
- Function: Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
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