CALCRL 抗体 (Extracellular) (PE)
Quick Overview for CALCRL 抗体 (Extracellular) (PE) (ABIN7582012)
抗原
See all CALCRL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 127-140, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Calcitonin Receptor-Like Receptor conjugated to the fluorescent dye R-Phycoerythrin
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序列
- CNVNTHEKVK TALN
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特异性
- Extracellular, N-terminus.
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预测反应
- Mouse,rat - 12 out of 14 amino acid residues identical
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产品特性
- Anti-CRLR/CALCRL (extracellular) Antibody (ABIN7042979, ABIN7044198 and ABIN7044199) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and live cell flow cytometry applications. It has been designed to recognize CALCRL from human, mouse and rat samples. Anti-CRLR/CALCRL (extracellular)-PE Antibody (ABIN7042979, ABIN7044198 and ABIN7044199-PE) is directly conjugated to R-Phycoerythrin (R-PE) fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CNVNTHEKVKTALN, corresponding to amino acid residues 127 - 140 of human Calcitonin Receptor-Like Receptor
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亚型
- IgG
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anti-Calcitonin Receptor-Like (CALCRL) (AA 127-140), (Extracellular) antibody
CALCRL 适用: 人 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (Cytoplasmic Domain) antibodyCALCRL 适用: 人, 大鼠, Cow, 犬, 马, 兔, 山羊, 猴, Hamster, Pig, 非洲爪蟾 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 23-132) antibodyCALCRL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 340-367) antibodyCALCRL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22070 unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (C-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 108-157) antibodyCALCRL 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 392-461) antibodyCALCRL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (N-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
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说明
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Negative Control: (ABIN7582046)
Blocking Peptide: (ABIN7234904)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CALCRL (Calcitonin Receptor-Like (CALCRL))
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别名
- CALCRL
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背景
- Calcitonin Receptor-Like Receptor, Calcitonin Gene-Related Peptide Type 1 Receptor, CRL, CGRPR,Calcitonin Receptor-Like Receptor 1 (CRLR or CGRPR) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism1.When engaged with its substrate, calcitonin gene related peptide (CGRP), CGRPR activates cAMP-dependent pkA and PI3 kinase, which eventually leads to complex inhibitory as well as facilitator actions on Neuronal Nicotinic Acetylcholine Receptor1.CGRP receptor is a heterodimer composed of two proteins: a 7-transmembrane domain type 2 G-protein coupled receptor called calcitonin-receptor-like receptor (CRLR), and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. RAMP1 serves as a transporter for CRLR to the cell surface and its absence leads to failure of binding with CRLR2.CGRP and CGRPR are ubiquitously expressed and their interaction is related to various diseases and health states such as migraines3 and Alzheimer's disease1.
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基因ID
- 10203
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UniProt
- Q16602
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途径
- cAMP Metabolic Process
抗原
-
