TAS1R3 抗体 (Extracellular)
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Quick Overview for TAS1R3 抗体 (Extracellular) (ABIN7581990)
抗原
See all TAS1R3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 508-521, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Taste Receptor Type 1 Member 3
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序列
- CKDGQVRRVK GFHS
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特异性
- Extracellular, N-terminus.
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预测反应
- Rat - identical, Human - 12,14 identical.
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产品特性
- Anti-Taste Receptor Type 1 Member 3 (TAS1R3) (extracellular) Antibody (ABIN7581990) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and flow cytometry applications. It has been designed to recognize TAS1R3 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CKDGQVRRVKGFHS, corresponding to amino acid residues 508 - 521 of mouse TAS1R3
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亚型
- IgG
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anti-Taste Receptor, Type 1, Member 3 (TAS1R3) (AA 400-570) antibody
TAS1R3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Taste Receptor, Type 1, Member 3 (TAS1R3) (AA 400-570) antibodyTAS1R3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Taste Receptor, Type 1, Member 3 (TAS1R3) (AA 326-375) antibodyTAS1R3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Antigen preadsorption control: 2 μg peptide per 1 μg antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TAS1R3 (Taste Receptor, Type 1, Member 3 (TAS1R3))
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别名
- TAS1R3
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背景
- Sweet Taste Receptor T1R3, T1R3,Taste receptor type 1 member 3 (TAS1R3), commonly known as T1R3, is a key component in the detection of sweet and umami tastes. TAS1R3 is part of the Class C G-protein-coupled receptor (GPCR) family and functions as a heterodimer with TAS1R1 or TAS1R2 to mediate umami and sweet taste perception, respectively. Structurally, members of this family share a large extracellular ligand-binding domain, seven transmembrane domains, and intracellular signaling regions1,3. TAS1R3 is localized primarily on the cell membrane of taste receptor cells within taste buds in the tongue's fungiform, foliate, and circumvallate papillae3,5. TAS1R3 expression extends to the gastrointestinal tract and specific enteroendocrine cells, linking its activation to nutrient sensing and gut hormone secretion2,4. Emerging evidence suggests that TAS1R3 is expressed in the hypothalamus, particularly in the paraventricular and arcuate nuclei, where it could play a role in integrating peripheral nutrient signals with neuroendocrine and behavioral responses6. Upon binding of sugars, amino acids, or fatty acids, TAS1R3 activates downstream signaling via the Gα-gustducin and phospholipase Cβ2 pathways, leading to calcium mobilization and neurotransmitter release3,5. TAS1R3-mediated signaling plays a significant role in nutrient detection, appetite regulation, and gut-brain axis communication. Dysfunction or altered TAS1R3 expression is implicated in metabolic disorders such as obesity, diabetes, and intestinal inflammation4.
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基因ID
- 83771
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UniProt
- Q925D8
抗原
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