SLIT1 抗体 (Secreted)
Quick Overview for SLIT1 抗体 (Secreted) (ABIN7581986)
抗原
See all SLIT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1170-1184, Secreted
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原理
- A Rabbit Polyclonal antibody to SLIT1
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序列
- (C)RDTYLQFTDL QNWPR
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特异性
- Secreted
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交叉反应 （详细）
- This antibody is specific to SLIT1, it won't recognize the highly homologous protein SLIT2.
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预测反应
- Human,rat - identical
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产品特性
- Anti-SLIT1 Antibody (ABIN7581986) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SLIT1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RDTYLQFTDLQNWPR, corresponding to amino acid residues 1170 - 1184 of mouse SLIT1
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亚型
- IgG
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anti-Slit Homolog 1 (SLIT1) (AA 647-835) antibody
SLIT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 603-773) antibodySLIT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 308-512) antibodySLIT1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 84-113) antibodySLIT1 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 611-791) antibodySLIT1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 455-500) antibodySLIT1 适用: 人 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 1439-1488) antibodySLIT1 适用: 人, Cow, 犬, 马, Pig, 兔, 斑马鱼, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 1315-1534) antibodySLIT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 345-623) antibodySLIT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Slit Homolog 1 (SLIT1) (AA 3-211) antibodySLIT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SLIT1 (Slit Homolog 1 (SLIT1))
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别名
- SLIT1
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背景
- Slit Guidance Ligand 1, Slit Homolog 1 Protein, Multiple EGF-Like Domains Protein 4, MEGF4,Slit homolog 1 protein (SLIT1), also known as multiple EGF-like domains protein 4, and MEGF4, is a secreted protein member of the SLIT family involved in axon guidance and cell migration.SLIT1 is a member of the SLIT family proteins that includes three members: SLIT1, SLIT2 and SLIT3. SLITS are secreted glycoproteins comprised of four stretches of leucine-rich repeat (LRR) domains, nine epidermal growth factor (EGF) repeats, a Laminin-G-like domain, and a C-terminal cysteine knot.1,2SLITS exert their many physiological roles by binding to Roundabout (Robo) receptors family, that includes four members (Robo 1 to Robo 4), which are single transmembrane receptors belonging to the immunoglobulin superfamily.1,2SLITS play a crucial role in axon guidance during the development of the nervous system. Axon guidance is the process by which neurons extend their axons to reach their appropriate targets, such as other neurons, muscles, or glands. This process is essential for the formation of functional neural circuits.1,3In addition, SLIT1 is involved in various aspects of the regulation of neural progenitor cells (NPCs). NPCs are the precursors to neurons and glial cells in the nervous system. They undergo proliferation, migration, and differentiation to generate the diverse cell types found in the mature brain. SLIT1 is involved in several aspects of NPCs functions, including promoting the proliferation of NPCs in several brain regions, guiding NPCs from the sub-ventricular zone towards the cortical plate and supporting the differentiation of NPCs into specific neuronal or glial cell types.3,4Finally, a complex role for SLIT1 in cancer has emerged. SLIT1 has been ascribed a tumor suppressive role in certain cancers such as breast and colorectal, while in others it appears to associate with tumor progression. In particular, in glioma and pancreatic cancer, SLIT1 expression has been correlated with enhanced metastasis formation and poor prognosis. 2,5,6
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基因ID
- 20562
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UniProt
- Q80TR4
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途径
- Regulation of Cell Size
抗原
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