SLC6A1 抗体 (Extracellular)
Quick Overview for SLC6A1 抗体 (Extracellular) (ABIN7581982)
抗原
See all SLC6A1 (GAT1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 194-206, Extracellular
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原理
- A Guinea Pig Polyclonal Antibody to GABA Transporter 1 (GAT-1) (extracellular)
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序列
- (C)ERNMHQMTDG LDK
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特异性
- 2nd extracellular loop
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预测反应
- Mouse,human - identical
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产品特性
- Guinea Pig Anti-GABA Transporter 1 (extracellular) Antibody (ABIN7581982) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-GABA Transporter 1 (extracellular) Antibody (ABIN7043178, ABIN7044459 and ABIN7044460) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ERNMHQMTDGLDK, corresponding to amino acids residues 194-206 of rat GAT-1
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亚型
- IgG
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anti-GABA Transporter 1 (GAT1) (AA 585-599) antibody
GAT1 适用: 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (Internal Region) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 大鼠, 小鼠 WB, IHC, ICC, IP 宿主: 豚鼠 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (C-Term) antibodyGAT1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (AA 473-487), (C-Term) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (Middle Region) antibodyGAT1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (C-Term) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235465)
Blocking Peptide: (ABIN7235465)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))
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别名
- SLC6A1
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背景
- GABATR, GABT1, GABATHG, Na+/Cl-- dependent GABA transporter 1, Solute Carrier Family 6 Member 1, SLC6A1,γ-Aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner1,2.To date, four GATs have been identified: GAT-1, GAT-2, GAT-3 and BGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini1. GATs couple the transport of one GABA molecule to 2 Na+ ions and one Cl- ion3. GAT-1 activity can be regulated at the level of its plasma membrane expression which is in part regulated by its trafficking via phosphorylation of residues in intracellular loops1.GAT-1 expression is restricted to the central nervous system, specifically to axon terminals, in the neocortex and in some astrocytic processes4.GAT-1 may be implicated in various psychological and neurological disorders such as schizophrenia, epilepsy and cerebral ischemia1,5-7.
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基因ID
- 79212
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UniProt
- P23978
抗原
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