SLC6A1 抗体 (2nd Extracellular Loop)
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北京 101111
Quick Overview for SLC6A1 抗体 (2nd Extracellular Loop) (ABIN7581982)
抗原
See all SLC6A1 (GAT1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 194-206
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原理
- A Guinea Pig Polyclonal Antibody to GABA Transporter 1 (GAT-1) (extracellular)
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序列
- (C)ERNMHQMTDG LDK
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预测反应
- Mouse,human - identical
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产品特性
- Guinea Pig Anti-GABA Transporter 1 (extracellular) Antibody (ABIN7581982) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-GABA Transporter 1 (extracellular) Antibody (ABIN7043178, ABIN7044459 and ABIN7044460) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ERNMHQMTDGLDK, corresponding to amino acids residues 194-206 of rat GAT-1
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亚型
- IgG
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anti-GABA Transporter 1 (GAT1) (AA 23-54), (N-Term) antibody
GAT1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (AA 585-599) antibodyKO Validated GAT1 适用: 大鼠, 小鼠 WB, IHC, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (Internal Region) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (AA 585-599) antibodyGAT1 适用: 大鼠, 小鼠 WB, IHC (p), IP, ICC 宿主: 豚鼠 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) antibodyGAT1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2390 unconjugated Recombinant Antibody
anti-GABA Transporter 1 (GAT1) (Middle Region) antibodyGAT1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (2nd Extracellular Loop), (AA 194-206) antibodyGAT1 适用: 大鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-GABA Transporter 1 (GAT1) (AA 324-373) antibodyGAT1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 猴, Pig, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235465)
Blocking Peptide: (ABIN7235465)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))
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别名
- SLC6A1
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背景
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Synonyms: GABATR, GABT1, GABATHG, Na+/Cl-- dependent GABA transporter 1, Solute Carrier Family 6 Member 1, SLC6A1
Description: γ-Aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner1,2.To date, four GATs have been identified: GAT-1, GAT-2, GAT-3 and BGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini1. GATs couple the transport of one GABA molecule to 2 Na+ ions and one Cl- ion3. GAT-1 activity can be regulated at the level of its plasma membrane expression which is in part regulated by its trafficking via phosphorylation of residues in intracellular loops1.GAT-1 expression is restricted to the central nervous system, specifically to axon terminals, in the neocortex and in some astrocytic processes4.GAT-1 may be implicated in various psychological and neurological disorders such as schizophrenia, epilepsy and cerebral ischemia1,5-7.
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基因ID
- 79212
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UniProt
- P23978
抗原
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